diff --git a/eng/pipelines/common/templates/runtimes/run-test-job.yml b/eng/pipelines/common/templates/runtimes/run-test-job.yml
index 706c8f1200495e..3f9374fcd5ce71 100644
--- a/eng/pipelines/common/templates/runtimes/run-test-job.yml
+++ b/eng/pipelines/common/templates/runtimes/run-test-job.yml
@@ -6,6 +6,8 @@ parameters:
   hostedOs: ''
   container: ''
   testGroup: ''
+  # ISA stress scenarios supplied by jit-outerloop-pipeline.yml.
+  jitIsaStressScenarios: []
   crossBuild: false
   readyToRun: false
   hotColdSplitting: false
@@ -383,38 +385,8 @@ jobs:
           scenarios:
           - jitstress_random_1
           - jitstress_random_2
-        ${{ if in(parameters.testGroup, 'jitstress-isas-arm') }}:
-          scenarios:
-          - jitstress_isas_nohwintrinsic
-        ${{ if in(parameters.testGroup, 'jitstress-isas-x86') }}:
-          scenarios:
-          - jitstress_isas_nohwintrinsic
-          - jitstress_isas_x86_evex
-          - jitstress_isas_x86_noavx
-          - jitstress_isas_x86_noavx2
-          - jitstress_isas_x86_noavx512
-          - jitstress_isas_x86_vectort128
-          - jitstress_isas_x86_vectort512
-          - jitstress_isas_x86_noavx512_vectort128
-          - jitstress_isas_1_x86_evex
-          - jitstress_isas_1_x86_noavx
-          - jitstress_isas_1_x86_noavx2
-          - jitstress_isas_1_x86_noavx512
-          - jitstress_isas_1_x86_vectort128
-          - jitstress_isas_1_x86_vectort512
-          - jitstress_isas_1_x86_noavx512_vectort128
-          - jitstress_isas_2_x86_evex
-          - jitstress_isas_2_x86_noavx
-          - jitstress_isas_2_x86_noavx2
-          - jitstress_isas_2_x86_noavx512
-          - jitstress_isas_2_x86_vectort128
-          - jitstress_isas_2_x86_vectort512
-          - jitstress_isas_2_x86_noavx512_vectort128
-        ${{ if in(parameters.testGroup, 'jitstress-isas-avx512') }}:
-          scenarios:
-          - jitstress_isas_x86_evex
-          - jitstress_isas_x86_noavx512
-          - jitstressregs0x2000
+        ${{ if in(parameters.testGroup, 'jitstress-isas-arm', 'jitstress-isas-avx512', 'jitstress-isas-x86') }}:
+          scenarios: ${{ parameters.jitIsaStressScenarios }}
         ${{ if in(parameters.testGroup, 'jitstressregs-x86') }}:
           scenarios:
           - jitstressregs1_x86_noavx
diff --git a/eng/pipelines/coreclr/templates/jit-isas-libraries.yml b/eng/pipelines/coreclr/templates/jit-isas-libraries.yml
new file mode 100644
index 00000000000000..8b034014b2c10d
--- /dev/null
+++ b/eng/pipelines/coreclr/templates/jit-isas-libraries.yml
@@ -0,0 +1,36 @@
+parameters:
+  - name: platforms
+    type: object
+  - name: scenarios
+    type: object
+
+stages:
+- stage: Libraries
+  displayName: Libraries Vector ISA Stress Tests
+  dependsOn: []
+  jobs:
+  - template: /eng/common/core-templates/job/helix-job-monitor.yml
+    parameters:
+      helixAccessToken: $(HelixApiAccessToken)
+      timeoutInMinutes: 540
+      allowNoHelixJobs: true
+
+  - template: /eng/pipelines/common/platform-matrix.yml
+    parameters:
+      jobTemplate: /eng/pipelines/common/global-build-job.yml
+      buildConfig: Release
+      helixQueueGroup: libraries
+      helixQueuesTemplate: /eng/pipelines/coreclr/templates/helix-queues-setup.yml
+      platforms: ${{ parameters.platforms }}
+      jobParameters:
+        nameSuffix: Libraries_VectorTests
+        # Default timeout is 150 minutes (2.5 hours), which is not enough for stress.
+        timeoutInMinutes: 360
+        buildArgs: -s clr+libs+libs.tests -rc Checked -c $(_BuildConfig) /p:ArchiveTests=true /p:RunVectorTestsOnly=true
+        postBuildSteps:
+          - template: /eng/pipelines/libraries/helix.yml
+            parameters:
+              creator: dotnet-bot
+              extraHelixArguments: /maxcpucount:10
+              useHelixMonitor: true
+              scenarios: ${{ parameters.scenarios }}
diff --git a/eng/pipelines/coreclr/templates/jit-outerloop-pipeline.yml b/eng/pipelines/coreclr/templates/jit-outerloop-pipeline.yml
index 41bea22cbb7f11..70874d47e0ab85 100644
--- a/eng/pipelines/coreclr/templates/jit-outerloop-pipeline.yml
+++ b/eng/pipelines/coreclr/templates/jit-outerloop-pipeline.yml
@@ -4,6 +4,38 @@ parameters:
   - name: testGroup
     type: string
     default: outerloop
+  - name: isaScenarios
+    type: object
+    default:
+      jitstress-isas-arm:
+      - jitstress_isas_nohwintrinsic
+      jitstress-isas-avx512:
+      - jitstress_isas_x86_evex
+      - jitstress_isas_x86_noavx512
+      - jitstressregs0x2000
+      jitstress-isas-x86:
+      - jitstress_isas_nohwintrinsic
+      - jitstress_isas_x86_evex
+      - jitstress_isas_x86_noavx
+      - jitstress_isas_x86_noavx2
+      - jitstress_isas_x86_noavx512
+      - jitstress_isas_x86_vectort128
+      - jitstress_isas_x86_vectort512
+      - jitstress_isas_x86_noavx512_vectort128
+      - jitstress_isas_1_x86_evex
+      - jitstress_isas_1_x86_noavx
+      - jitstress_isas_1_x86_noavx2
+      - jitstress_isas_1_x86_noavx512
+      - jitstress_isas_1_x86_vectort128
+      - jitstress_isas_1_x86_vectort512
+      - jitstress_isas_1_x86_noavx512_vectort128
+      - jitstress_isas_2_x86_evex
+      - jitstress_isas_2_x86_noavx
+      - jitstress_isas_2_x86_noavx2
+      - jitstress_isas_2_x86_noavx512
+      - jitstress_isas_2_x86_vectort128
+      - jitstress_isas_2_x86_vectort512
+      - jitstress_isas_2_x86_noavx512_vectort128
   - name: stages
     type: stageList
     default: []
@@ -56,7 +88,14 @@ extends:
           helixQueuesTemplate: /eng/pipelines/coreclr/templates/helix-queues-setup.yml
           jobParameters:
             testGroup: ${{ parameters.testGroup }}
+            ${{ if in(parameters.testGroup, 'jitstress-isas-arm', 'jitstress-isas-avx512', 'jitstress-isas-x86') }}:
+              jitIsaStressScenarios: ${{ parameters.isaScenarios[parameters.testGroup] }}
             liveLibrariesBuildConfig: Release
             unifiedArtifactsName: BuildArtifacts_$(osGroup)$(osSubgroup)_$(archType)_$(_BuildConfig)
+    - ${{ if in(parameters.testGroup, 'jitstress-isas-arm', 'jitstress-isas-avx512', 'jitstress-isas-x86') }}:
+      - template: /eng/pipelines/coreclr/templates/jit-isas-libraries.yml
+        parameters:
+          platforms: ${{ parameters.platforms }}
+          scenarios: ${{ parameters.isaScenarios[parameters.testGroup] }}
     - ${{ each stage in parameters.stages }}:
         - ${{ stage }}
diff --git a/src/libraries/tests.proj b/src/libraries/tests.proj
index 9f48d7b47b225b..d3649497414602 100644
--- a/src/libraries/tests.proj
+++ b/src/libraries/tests.proj
@@ -662,6 +662,15 @@
     <ProjectExclusions Include="$(MSBuildThisFileDirectory)System.Text.RegularExpressions/tests/FunctionalTests/System.Text.RegularExpressions.Tests.csproj" />
   </ItemGroup>
 
+  <!-- Focus ISA stress on vector APIs and algorithms without building the full test suite. -->
+  <ItemGroup Condition="'$(RunVectorTestsOnly)' == 'true'">
+    <VectorTestProject Include="$(MSBuildThisFileDirectory)System.Linq\tests\System.Linq.Tests.csproj" />
+    <VectorTestProject Include="$(MSBuildThisFileDirectory)System.Memory\tests\System.Memory.Tests.csproj" />
+    <VectorTestProject Include="$(MSBuildThisFileDirectory)System.Numerics.Tensors\tests\System.Numerics.Tensors.Tests.csproj" />
+    <VectorTestProject Include="$(MSBuildThisFileDirectory)System.Numerics.Vectors\tests\System.Numerics.Vectors.Tests.csproj" />
+    <VectorTestProject Include="$(MSBuildThisFileDirectory)System.Runtime.Intrinsics\tests\System.Runtime.Intrinsics.Tests.csproj" />
+  </ItemGroup>
+
   <ItemGroup>
     <ProjectReference Condition="'$(RunSmokeTestsOnly)' == 'true'"
                       Include="@(SmokeTestProject)" />
@@ -676,7 +685,12 @@
 
     <ProjectReference Include="$(MSBuildThisFileDirectory)*\tests\**\*.Tests.csproj"
                       Exclude="@(ProjectExclusions)"
-                      Condition="'$(TestAssemblies)' == 'true'"
+                      Condition="'$(TestAssemblies)' == 'true' and '$(RunVectorTestsOnly)' != 'true'"
+                      BuildInParallel="$(BuildTestInParallel)" />
+
+    <ProjectReference Include="@(VectorTestProject)"
+                      Exclude="@(ProjectExclusions)"
+                      Condition="'$(TestAssemblies)' == 'true' and '$(RunVectorTestsOnly)' == 'true'"
                       BuildInParallel="$(BuildTestInParallel)" />
 
     <ProjectReference Include="$(MSBuildThisFileDirectory)testPackages\testPackages.proj"