diff --git a/src/coreclr/vm/threads.cpp b/src/coreclr/vm/threads.cpp
index e06b9300655136..f6fd26a4a74392 100644
--- a/src/coreclr/vm/threads.cpp
+++ b/src/coreclr/vm/threads.cpp
@@ -611,7 +611,11 @@ Thread* SetupThread()
     if ((pThread = GetThreadNULLOk()) != NULL)
         return pThread;
 
+#ifndef TARGET_APPLE
+    // Disable the check on Apple platforms
+    // See https://github.com/dotnet/runtime/issues/134571
     CheckThreadStateNotDestroyed();
+#endif
 
     // For interop debugging, we must mark that we're in a can't-stop region
     // b.c we may take Crsts here that may block the helper thread.
diff --git a/src/tests/baseservices/threading/ThreadStateDestroyed/ThreadStateDestroyed.csproj b/src/tests/baseservices/threading/ThreadStateDestroyed/ThreadStateDestroyed.csproj
index bd6b31acc80d27..d141302f1e0374 100644
--- a/src/tests/baseservices/threading/ThreadStateDestroyed/ThreadStateDestroyed.csproj
+++ b/src/tests/baseservices/threading/ThreadStateDestroyed/ThreadStateDestroyed.csproj
@@ -7,6 +7,8 @@
     <GCStressIncompatible>true</GCStressIncompatible>
     <NativeAotIncompatible>true</NativeAotIncompatible>
     <CLRTestTargetUnsupported Condition="'$(TargetsAppleMobile)' == 'true' or '$(TargetsAndroid)' == 'true' or '$(TargetsBrowser)' == 'true' or '$(TargetsWasi)' == 'true'">true</CLRTestTargetUnsupported>
+    <!-- ActiveIssue https://github.com/dotnet/runtime/issues/134571 -->
+    <CLRTestTargetUnsupported Condition="'$(TargetsOSX)' == 'true'">true</CLRTestTargetUnsupported>
     <CLRTestTargetUnsupported Condition="'$(RuntimeFlavor)' != 'coreclr'">true</CLRTestTargetUnsupported>
   </PropertyGroup>
   <ItemGroup>