diff --git a/src/coreclr/nativeaot/System.Private.CoreLib/src/System/Runtime/TypeLoaderExports.cs b/src/coreclr/nativeaot/System.Private.CoreLib/src/System/Runtime/TypeLoaderExports.cs
index 6d71f0d880d0af..29500cf3089961 100644
--- a/src/coreclr/nativeaot/System.Private.CoreLib/src/System/Runtime/TypeLoaderExports.cs
+++ b/src/coreclr/nativeaot/System.Private.CoreLib/src/System/Runtime/TypeLoaderExports.cs
@@ -111,10 +111,19 @@ public static object GenericLookupAndCast(object arg, IntPtr context, IntPtr sig
 
         public static unsafe IntPtr GVMLookupForSlot(object obj, RuntimeMethodHandle slot)
         {
-            Entry entry = LookupInCache(s_cache, (IntPtr)obj.GetMethodTable(), *(IntPtr*)&slot);
-            entry ??= CacheMiss((IntPtr)obj.GetMethodTable(), *(IntPtr*)&slot,
+            Entry entry = LookupInCache(s_cache, (IntPtr)obj.GetMethodTable(), RuntimeMethodHandle.ToIntPtr(slot));
+            if (entry != null)
+                return entry.Result;
+
+            return GVMLookupForSlotSlow(obj, slot);
+        }
+
+        private static unsafe IntPtr GVMLookupForSlotSlow(object obj, RuntimeMethodHandle slot)
+        {
+            Entry entry = CacheMiss((IntPtr)obj.GetMethodTable(), RuntimeMethodHandle.ToIntPtr(slot),
                     (IntPtr context, IntPtr signature, object contextObject, ref IntPtr auxResult)
                         => RuntimeAugments.TypeLoaderCallbacks.ResolveGenericVirtualMethodTarget(new RuntimeTypeHandle(new EETypePtr(context)), *(RuntimeMethodHandle*)&signature));
+
             return entry.Result;
         }
 
@@ -133,7 +142,11 @@ internal static unsafe IntPtr OpenInstanceMethodLookup(IntPtr openResolver, obje
         private static Entry LookupInCache(Entry[] cache, IntPtr context, IntPtr signature)
         {
             int key = ((context.GetHashCode() >> 4) ^ signature.GetHashCode()) & (cache.Length - 1);
+#if DEBUG
             Entry entry = cache[key];
+#else
+            Entry entry = Unsafe.Add(ref MemoryMarshal.GetArrayDataReference(cache), key);
+#endif
             while (entry != null)
             {
                 if (entry.Context == context && entry.Signature == signature)