A curated list of fruit fly connectome projects: MaleCNS, FlyWire, brain simulations, embodied models, games, and research tools.
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Updated
Sep 20, 2026
A curated list of fruit fly connectome projects: MaleCNS, FlyWire, brain simulations, embodied models, games, and research tools.
A fruit fly connectome as a drone pilot. Camera -> fly eyes -> spiking brain -> descending neurons -> drone. Live 3D demo in your browser.
Real fly anatomy and model-output starter. Custom license requires web UI and repository attribution.
A fruit fly connectome (MaleCNS v1.0) trading an intraday NIFTY straddle through OpenAlgo.
Five fruit flies pinned to electric pins. A sixth fly, wired into a reward-punishment loop, decides which two get current, gets dopamine when one maxes out, and burns when the others go cold. Six copies of the MaleCNS connectome, 166,700 neurons each, bit-identical until something is done to them. [Look at the bottom of the README]
Native .NET inference engine for fly-connectome spiking models (MaleCNS, FlyWire) — and an honest demo of what such simulations are
Behavioural benchmark for whole-brain fruit fly connectome simulations: 31 pre-registered, cited tasks on FlyWire v783 and MaleCNS, shuffled-wiring controls, a reference LIF and the first cross-model comparison (spike-frequency adaptation beats it).
No CUDA required. Open-source Python connectome simulation SDK: CPU LIF runtime, game APIs, checkpoints, and on-demand MaleCNS/FlyWire data.
Interactive 3D Drosophila brain atlas and local connectomics research lab. Explore MaleCNS anatomy, train connectome-based neural networks, and evaluate neural architecture search with reproducible PyTorch experiments.
The fruit fly connectome (FlyWire v783, MaleCNS) running as a spiking network live in your browser. Press sugar, watch the proboscis motor neuron fire; permalink any experiment; every result scored on flybench.
Fruit Fly (Drosophila MaleCNS v1.0) biological connectome playing Microsoft Minesweeper with real-time 3D WebGL neural activity HUD. Built in PyTorch & Three.js.
malecns 驱动的 🪰 格斗小游戏
Inspectable fruit-fly neural simulation built from the official MaleCNS connectome, with foraging, learning, gym experiments, and a Three.js/WebGPU observatory.
A 3D site for kids and teens built on the real MaleCNS fruit-fly connectome: 140,024 neurons at their measured positions, replaying an escape reflex simulated on their real wiring.
CNS Rover — Connectome-guided robot navigation
A fruit fly's brain beat Claude, GPT-5, Grok and Gemini at judging health records. Code, data and paper for SuperTruth's connectome study: the MaleCNS v1.0 fly nervous system held fixed and trained to reproduce the Data Trust Index on synthetic health records, against five controls. Pre-registered, published win or lose. DOI 10.5281/zenodo.22865215
Experimental framework for running, visualizing, and evaluating machine-learning experiments on Drosophila connectomes, starting with MaleCNS visual memory and lesion-recovery studies.
166,700 real fruit fly neurons, two swords, one arena. No training or reward function, aggression is octopamine and the dodge is the giant fiber escape circuit.
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